Irf8 flox mouse

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August undefined, 2024

WebIRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. … WebCreLysMFasflox/flox mice expressed Fas on B and T lym-phocytes isolated from peripheral blood (ref. 10 and data not shown) and the peritoneal cavity (Figure 1A). In contrast, Fas …

IRF8 - an overview ScienceDirect Topics

WebFigure Legend Snippet: Upregulation of downstream targets of ERK pathway. A. Western Blot analysis of protein extract from normal appearing mucosa obtained from small intestines tissues from LSL-K-RasG12D and Villin-Cre/LSL-K-RasG12D mice. 10 ug of total protein extracts from LSL-K-RasG12D and Villin-Cre/LSL-K-RasG12D were analyzed by Western … http://www.dukecancerinstitute.org/transgenic-and-knockout-mouse dickies arena account

Transgenic and Knockout Mouse Duke Cancer Institute

Web品系描述. 通过在Tnfrsf8基因exon 2两侧分别插入loxP位点。. 该flox小鼠可与组织特异性Cre工具鼠交配，获得在特定细胞类型或组织中敲除Tnfrsf8基因的小鼠模型。. WebJun 21, 2024 · We generated a mouse line with Irf8 -deficiency in Clec9a -expressing progenitors and hypothesized that Irf8 -deficiency would deplete cDC1s, which may promote a pro-inflammatory immune response and consequently drive AKI/AKD progression. Materials and Methods Animals WebOct 1, 2024 · The IRF8 FLOX mice (C57BL/6J background) were kindly provided by professor Hongliang Li (Wuhan University, China). The hepatocyte-specific IRF8-knockout mice … dickies arena address in fort worth

Ab production in mice immunized with NP-LPS, NP-FICOLL

Frontiers IRF8-Dependent Type I Conventional Dendritic …

WebMar 8, 2024 · Because IRF8 may contribute to SSc progression, including fibrosis, vascular abnormalities, and impaired wound healing, we evaluated IRF8 levels in SSc monocytes … citizenship shipperWebMyeloid cell-specific IRF8 conditional knockout mice (IRF8flox/flox; Lyz2Cre/+) with a C57BL/6 background were generated by mating IRF8-flox mice (Feng et al. 2011) with Lyz2-Cre knock-in mice. The primers used for genotyping are shown in Supplementary Table S3. The genotyping results are shown in Supplementary Figure S4a. Harvesting of blood ... citizenship services canada

"WebAug 1, 2024 · Finally, we assessed skin fibrosis in myeloid cell–specific IRF8 conditional knockout (Irf8 flox /flox; Lyz2 Cre/+) mice and found upregulated mRNA levels of extracellular matrix components and increased bleomycin-induced skin fibrosis. In conclusion, altered IRF8 regulation in monocytes and macrophages may be involved in … " - Irf8 flox mouse

Irf8 flox mouse

WebProduct Specific Information. Description: The V3GYWCH monoclonal antibody reacts with human and mouse interferon regulatory factor 8 (IRF8; ICSBP). IRF8 is a 50 kDa transcription factor that plays a critical role in the development of dendritic cells (DC). Specifically, IRF8 is essential in the development and differentiation of plasmacytoid ... WebIRF8 Model Description These mice carry loxP sites flanking exon 3-6 of Irf8 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Irf8 gene. Related Strain (s) Irf8-KO Strain Name： C57BL/6JSmoc- Irf8em1Smoc

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WebMice in which the gene expressing B 2 receptor has been specifically deleted from the endothelium (B 2 flox/flox.Tie2 Cre) presented normal blood pressure readings compared … WebIRF8 and IRF1 are transcriptional regulators that play critical roles in the development and function of myeloid cells, including activation of macrophages by proinflammatory signals …

WebEarly life and education. Fredericks was born of Scandinavian descent in Rock Island, Illinois, on January 31, 1908. [citation needed] His family moved to Florida for a short time and … Web014175 B6.Cg- Irf8 tm1.1Hm /J This Irf8 f floxed targeted mutation strain may be useful in generating conditional mutants for studying B cell differentiation, immunodeficiency …

WebCopies of IRF8 flox or delta locus/ reference gene locus CD45.2 (normalized) ... Mononuclear phagocyte composition in Itgax-cre.Irf8fl/fl or fl/- and Irf8fl/fl mice and effect of Irf8 haplo-insufficiency on intestinal DC subset composition, related to Figure 1. (A and C) Representative flow cytometry plots and (B and D) ... WebDec 11, 2024 · Mice with IRF8 deficiency only in colon epithelial cells (termed IRF8cKO) were created by crossing Irf8-floxed mice with villin-cre mice (Figures S1A and S1B) with the deletion of exon 2 (Figure S1C). As reported in the literature, we observed that IRF8KO mice exhibit elevated levels of CD11b + Gr1 + MDSCs as compared to wild-type (WT) mice. …

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WebThe Kynu gene ( NCBI Reference Sequence: NM_027552.2 ; Ensembl: ENSMUSG00000026866 ) is located on mouse chromosome 2. Fourteen exons are identified , with the ATG start codon in exon 2 and the TAG stop codon in exon 14 (Transcript Kynu- 201: ENSMUST00000028223). Exon 3 will be selected as target site. Cas9 and gRNA will … citizenship seven caseWebInterferon regulatory factor 8 (Irf8) is a transcription factor that negatively regulates osteoclast differentiation and Irf8 global knockout (Irf8 -/-) mice have been shown to have … dickies arena arlingtonWebThe Transgenic and Knockout Mouse Shared Resource provides members of the DCI with comprehensive and user-friendly services for the production of custom designed, … citizenships for saleWebJan 1, 2014 · Here we show that IRF8 is downregulated in both mouse hearts and cardiomyocytes after hypertrophic stress treatment. Moreover, IRF8-deficient mice reveal an aggravated pressure overload-induced hypertrophic response, whereas the opposite effects occur in IRF8-overexpressing mice. dickies arena box office hoursWebIRF8 is a transcriptional regulator that is essential for the differentiation and function of monocytes and macrophages and thus may be involved in the regulation of macrophage … dickies arena box officeWebInterferon regulatory factor (IRF) 8 is a transcriptional regulator that is essential for the differentiation and function of monocytes and macrophages, and thus may be involved in the regulation... dickies arena box office locationWebLocomotion in Nkx6.2-null mice (n = 10) was characterized by an increased number of steps during the same period of time compared to control mice (n = 15), without any change in … citizenship shipping