Griffithsin virus patent

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August undefined, 2024

WebDec 16, 2010 · Background Griffithsin, a 121-residue protein isolated from a red algal Griffithsia sp., binds high mannose N-linked glycans of virus surface glycoproteins with extremely high affinity, a property that allows it to prevent the entry of primary isolates and laboratory strains of T- and M-tropic HIV-1. We used the sequence of a portion of … WebOct 6, 2024 · Virus entry into a susceptible host cell is the first step in the formation of all viral diseases. Controlling viral infections by disrupting viral entry is advantageous for …

A new way to make a virus-fighting protein could save …

WebOn December 1, 2006, the patent was filed and granted – U.S. Patent #US 8088729 B2. The interesting thing here is that the inventors of the patent are listed as: Barry O’Keefe, … WebApr 19, 2024 · The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, … he kingfish fancy herring snacks

Marine Drugs Free Full-Text Griffithsin, a Highly Potent Broad ...

WebNov 16, 2024 · Q-Griffithsin (Q-GRFT) nasal spray is an investigational product that has broad spectrum antiviral activity. Q-GRFT is derived from Griffithsin (GRFT) a naturally occurring protein originally isolated from the red alga Griffithsia found in the South Pacific Ocean. For the purposes of this study GRFT has been genetically modified to produce a ... WebAug 21, 2024 · For these indications, the annual demand for Griffithsin could reach billions of doses and affordability is paramount. We report the lab-scale validation of a bioprocess that supports production volumes of >20 tons per year at a cost of goods sold below $3,500/kg. Recombinant expression in engineered E. coli enables Griffithsin titers ∼2.5 … WebCDC tested a broad-spectrum antiviral from a protein found in red alga, Griffitshia sp., that offers a low-cost way to potentially prevent or treat infections from rabies virus. Researchers determined that Griffithsin (GRFT) neutralizes rabies virus (RABV) activity in vitro and in vivo. Currently, with the exception of RIG and another ... he king of fighters

Griffithsin Inhibits Nipah Virus Entry and Fusion and Can …

WebJul 19, 2024 · Griffithsin works by binding to viruses, preventing them from infecting cells in both animals and humans. “The nice thing about Q-griffithsin is that it has a number of activities against other... WebIn particular, a red algae-derived griffithsin (GRFT) protein has demonstrated superior in vitro and in vivo antiviral activity with minimum host toxicity against a variety of clinically relevant, enveloped viruses. This review examines the structural characteristics of GRFT, focusing on its carbohydrate-binding capability. he knew exacWebJan 23, 2015 · The lectin griffithsin (GRFT) is a potent antiviral agent capable of prevention and treatment of infections caused by a number of enveloped viruses and is currently … he knelt to the ground

"WebUS10501507B2 US15/550,323 US201615550323A US10501507B2 US 10501507 B2 US10501507 B2 US 10501507B2 US 201615550323 A US201615550323 A US 201615550323A US 10501507 B2 US10501507 B2 " - Griffithsin virus patent

Griffithsin virus patent

US10501507B2 - Griffithsin mutants - Google Patents

WebAug 2, 2011 · Many natural product-derived lectins such as the red algal lectin griffithsin (GRFT) have potent in vitro activity against viruses that display dense clusters of … WebJul 8, 2024 · In addition, Griffithsin could be used in combination with other anti-viral agents to treat patients who have drug-resistant virus. A related NCI invention, reference …

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WebDec 1, 2006 · US Patent for Anti-viral griffithsin compounds, compositions and methods of use Patent (Patent # 8,088,729 issued January 3, 2012) - Justia Patents Search Anti-viral griffithsin compounds, compositions and methods of use Dec 1, 2006 - The United States of America as represented by the Secretary, Department of Health and Human Services WebGriffithsin, a potent HIV entry inhibitor, is an excellent candidate for anti-HIV microbicide The in vitro efficacy of GRFT revealed low cytotoxicity, high potency, rapid onset of antiviral activity and long-term stability in cervical/vaginal lavage. GRFT is an excellent candidate for anti-HIV microbicide development.

WebDec 1, 2006 · A method of inhibiting a viral infection of a host comprising administering to the host an anti-viral griffithsin polypeptide comprising SEQ ID NO: 3 or a fragment … WebGriffithsin is moving into clinical trials as an anti-HIV microbicide. Based on the structure of griffithsin and the necessities of pharmaceutical product development and regulatory …

WebA method of inhibiting a viral infection of a host comprising administering to the host an anti-viral griffithsin polypeptide comprising SEQ ID NO: 3 or a fragment thereof comprising at least eight contiguous amino acids, a nucleic acid encoding the anti-viral polypeptide, or an antibody to the anti-viral polypeptide. A method of inhibiting a virus in a sample … WebNational Center for Biotechnology Information

Requests for copies of the patent applications, inquiries, and comments relating to the contemplated exclusive patent license should be directed to: Taryn Dick, Ph.D., MBA, Licensing and Patenting Manager at Telephone: (301) 631-3007 or Email: [email protected]. See more The National Cancer Institute (NCI), National Institutes of Health, Department of Health and Human Services, is contemplating the grant of an exclusive, sublicensable patent … See more Only written comments and/or applications for a license which are received by the NCI Technology Transfer Center January 12, 2024 will be considered. See more The following and all continuing U.S. and foreign patents/patent applications thereof are the intellectual properties to be licensed under the prospective agreement to ULRF: U.S. … See more

WebJan 23, 2015 · The lectin griffithsin (GRFT) is a potent antiviral agent capable of prevention and treatment of infections caused by a number of enveloped viruses and is currently under development as an anti-HIV microbicide. he king\u0027s cross william ivWebOct 24, 2016 · Griffithsin (GRFT), an algae-derived lectin, is one of the most potent viral entry inhibitors discovered to date. It is currently being developed as a microbicide with broad-spectrum activity... he king\\u0027s cross william ivWebGriffithsin, a Highly Potent Broad-Spectrum Antiviral Lectin from Red ... he knew he f\u0027d up audioWebOct 24, 2016 · Griffithsin (GRFT), an algae-derived lectin, is one of the most potent viral entry inhibitors discovered to date. It is currently being developed as a microbicide with … he kitchen \u0026 coWebOct 6, 2024 · Virus entry into a susceptible host cell is the first step in the formation of all viral diseases. Controlling viral infections by disrupting viral entry is advantageous for antibody-mediated neutralization by the host’s immune system and as a preventive and therapeutic antiviral strategy. Recently, several plant-derived carbohydrate-binding … he kitxhen black forest overnifhr oatmealWebOct 6, 2024 · Griffithsin, a Highly Potent Broad-Spectrum Antiviral Lectin from Red Algae: From Discovery to Clinical Application Mar Drugs. 2024 Oct 6;17(10):567.doi: 10.3390/md17100567. Author Choongho Lee 1 Affiliation 1College of Pharmacy, Dongguk University, Goyang 10326, Korea. [email protected]. PMID: he knew diatWebDec 9, 2024 · The University of Louisville has received funding from the U.S. Department of Defense (DoD) to develop a nasal spray to prevent serious viral respiratory infections such as COVID-19 using... he knew he f\\u0027d up